It is a cross over between the series Lupin III and Detective Conan and takes place after the television special Lupin the 3rd vs Detective Conan. The plot follows Conan Edogawa who sets out to apprehend Arsène Lupin III, the suspect of stealing a jewel called Cherry Sapphire.

Lupin & co. compete with a greedy bank president and her goons to solve the mystery leading to a broach, a treasure said to be behind the success of history's most powerful rulers.

Lupin & co. compete with a greedy bank president and her goons to solve the mystery leading to a broach, a treasure said to be behind the success of history's most powerful rulers.

When Fujiko acquires and memorizes papers called the Columbus Files, she is attacked and loses her memory. Lupin, a treasure hunter named Rosaria, and the cackling villain Nazaroff all pursue Fujiko, as she is the only key to the location of Columbus' Egg, a treasure connected to the mysterious Orgone Energy.

Zenigata arrives on the ship "Machine Gun Kelly", a casino on the water owned by the mafia, because Lupin plans on stealing the casino's money. Lupin and his gang manages to break into the ship's vault but was unable to escape with the money due to Zenigata's shooting. However, there was another purpose the ship had, one that Lupin was aware of; to search for a sunken ship filled with gold. Lupin managed to steal this data while he was on the ship, however, now they have to contend with Zenigata, the mafia, and a secret organization whose base is under Alcatraz, as they attempt to uncover the secret behind the organization and the sunken treasure.

Mysterious Babylonian Tablets unearthed in Manhattan provide tantilizing clues about the location of the Tower of Babel - not the biblical one, but the original one, built out of solid gold! The Mob is out to get the gold, but so is Lupin III. It's Thugs vs. Thieves when Lupin & Co. go up against a fearsome flyswatting Polish Mafia boss, a bevy of beauty-contest policewomen, Zenigata, the hard-luck Interpol Inspector, a mysterious bag-lady AND his own girl-friend in a trans-continental trust-nobody trek after a treasure of biblical proportions!

Mysterious Babylonian Tablets unearthed in Manhattan provide tantilizing clues about the location of the Tower of Babel - not the biblical one, but the original one, built out of solid gold! The Mob is out to get the gold, but so is Lupin III. It's Thugs vs. Thieves when Lupin & Co. go up against a fearsome flyswatting Polish Mafia boss, a bevy of beauty-contest policewomen, Zenigata, the hard-luck Interpol Inspector, a mysterious bag-lady AND his own girl-friend in a trans-continental trust-nobody trek after a treasure of biblical proportions!

Two jewels are the key to the ancient treasure of Yaobikuni. But legend has it that the only person who can find the treasure is one who can walk the path of death.And why is Lupin interested? This is the one treasure his grandfather sought but did not steal.

In this adventure, Lupin III tries to erase the files about him in the world police network. He finds out about the Ultravirus, a computer virus that controls all others and its location is only known by a little kid. Meanwhile, he steals the Statue of Liberty to look for a diamond the size of a football that is said to be hidden somewhere in it. Apparently, the diamond and the ultravirus are somehow related...

In this adventure, Lupin III tries to erase the files about him in the world police network. He finds out about the Ultravirus, a computer virus that controls all others and its location is only known by a little kid. Meanwhile, he steals the Statue of Liberty to look for a diamond the size of a football that is said to be hidden somewhere in it. Apparently, the diamond and the ultravirus are somehow related... (Source: ANN)

Two jewels are the key to the ancient treasure of Yaobikuni. But legend has it that the only person who can find the treasure is one who can walk the path of death. And why is Lupin interested? This is the one treasure his grandfather sought but did not steal.

Lupin, Goemon, and Jigen take a mini-helicopter and head to the mysterious “Drifting Island” looking for a treasure rumored to be hidden somewhere on it. Through their exploration of the island, the trio encounters the lethal “Nanomachine,” the island’s security system. The trio triggers the alarm, springing “the Nanomachine” to life. The key to solving the island’s mystery lies in the small nation of Zufu. This once prosperous nation is now ruled by the ruthless, knife-collecting, General Headhunter. Fujiko does her usual probing and hacks into General Headhunter’s computer hoping to find some crucial information. Zenigata has received a video message from Lupin in which Lupin announces his desire for the priceless treasure. Oleander, a fiery blond officer with some hidden secrets of her own, steps in to help Zenigata. Armed with their newly found information, Lupin, Goemon, Jigen, and Fujiko go back to “Drifting Island,” but this time they are followed by General Headhunter.